Ginseng has been used for centuries as a traditional Chinese medicine to help improve cognitive function, increase energy and endurance, reduce inflammation, increase immunity, and alleviate stress and anxiety.
Ginsenosides are the active ingredient in ginseng that are responsible for a variety of health-promoting effects of ginseng. There are more than 100 different types of ginsenosides, with major and minor ginsenosides being the two main categories.
Major ginsenosides are the most abundant and highly researched compounds found in ginseng. These ginsenosides include Rg1, Rb1, Rg3, and Rd, among others.
Minor ginsenosides, also known as rare ginsenosides or noble ginsenosides, on the other hand, are nearly not present in the ginseng plants. These ginsenosides are produced through the metabolism of major ginsenosides by intestinal bacteria and include Rg2, Rg5, Rk1, Rh4, Rk2, etc.
The major ginsenosides are not absorbed well in the human intestinal tract, whereas the minor ginsenosides have better bioactivity and absorption due to their deglucosylation to have a small molecule weight, resulting in superior pharmacological activity as compared to that of the major ginsenosides.
Currently, major ginsenosides can be transformed to minor ginsenosides by various methods, including heat treatment, acid hydrolysis, enzymatic conversion, microbial biotransformation, as well as Ultraviolet (UV) irradiation.
Take heat treatment for example, when ginseng is processed through steaming, the major ginsenosides like Rb2, Rb1, Re, Rg1, and Rc decreases, but the minor ginsenosides with superior pharmacological activities, such as Rg2, Rg3, Rg5, Rh1, Rh2, Rh3, and Rh4, increases with heating time.
The rare, minor ginsenosides hold the key to unlocking even greater health benefits. However, the mass production of minor ginsenosides is a challenge for many manufacturers, and most ginseng supplements on the market still feature major ginsenosides. That is where Canada Royal Enoch Phytomedicine comes in.
Canada Royal Enoch Phytomedicine is the world’s only producer to have invented four different core technologies that enable the extraction, processing, transformation, and formulation of rare ginsenosides. Its flagship product, Redsenol-1 Plus Noble Ginsenoside Capsules, contains highly bioactive and absorbable rare ginsenoside monomers, more potent than common Panax/Korean red ginseng extracts. These capsules have an impressive rare ginsenoside content of up to 20%, including compounds such as Rg3(R, S), Rh1(S, R), Rh2(R, S), Rk1, Rk3, Rg5, Rh3, Rh4, Rk2, aPPD(S, R), and aPPT(S, R).
Moreover, further conversion of rare ginsenosides can lead to the production of super highly bioactive compounds that are small enough to penetrate the blood-brain barrier and reach the intended site of action in the brain. Redsenol Dag Noble Ginsenoside Sublingual Pills are a prime example of this, containing highly bioactive rare ginsenosides like Rk1, Rg5, Rh3, Rk2, aPPD (S, R), and aPPT (S, R).
Redsenol has extensively made a name for itself as a trusted and reliable ginseng supplement brand, with a growing base of loyal customers around the world. This year, the company is taking things to the next level by conducting a clinical trial to test the efficacy of Redsenol-1 Plus Noble Ginsenosides for treating cancer-related fatigue among cancer patients who have received cancer treatment.
As more research is conducted on rare ginsenosides, it becomes increasingly clear that these compounds hold the key to unlocking even greater health benefits from ginseng. With its innovative approach to producing rare ginsenosides, Redsenol is a pioneer in utilizing these compounds to their fullest potential.