Home Ginseng & Ginsenosides Rare Ginsenosides block Vitamin D3 inactivation in human liver and intestine in...

Rare Ginsenosides block Vitamin D3 inactivation in human liver and intestine in vitro

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The author investigated the potential of rare ginsenosides and their aglycones to block hepatic and intestinal inactivation of 1α,25(OH)2D3, which is the most potent ligand of vitamin D receptor. The results suggest that rare ginsenosides, specifically aPPD and aPPT, inhibit the CYP3A4-mediated catabolism of active vitamin D3 in human liver and intestine, potentially providing additional vitamin D-related benefits to patients with cancer, neurodegenerative and metabolic diseases.

Reference:

https://www.ncbi.nlm.nih.gov/pubmed/24486455

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