Home Ginseng & Ginsenosides Rare ginsenosides could induce apoptosis in cervical cancer cell lines

Rare ginsenosides could induce apoptosis in cervical cancer cell lines


Rare ginsenosides could induce apoposis in cervical cancer linesGinseng is a widely used medicinal herb, and people use it for health purposes, including energy boost, fatigue resistance, stress ameliorating, immune enhancement, etc.

It is one of the most commonly used complementary and alternative therapies, in combination with traditional therapies, among cancer patients.

A trial result at the ASCO cancer conference showed that ginseng could reduce cancer-related fatigue. Cancer patients who took 2,000 mg of American ginseng per day for 8 weeks had had significantly lower fatigue scores, compared to those in the placebo group.

The molecules that are responsible for the medicinal properties of ginseng are known as ginsenosides, and they have exhibited brilliant antitumor activities in preclinical studies.

The naturally occurring ginsenosides in ginseng are high-molecular-weight and are not easy to be absorbed by human bodies. They can be further metabolized and transformed into low-molecular-weight rare ginsenosides by losing some glycosyl moieties to improve bioactivity and absorption. Some rare ginsenosides include Rh2, Rg3, Rg5, Rk1, Rh3, Rk2, etc.

Rare ginsenoside Rh2 is a metabolized rare ginsenoside that is converted from the naturally existing ginsenoside Rb1 in ginseng.

A recent study found that ginsenoside Rh2 could repress autophagy to promote cervical cancer cell apoptosis during starvation.

The finding is not supervising because ginsenoside Rh2 has been found to effectively inhibit the growth and proliferation of cancer cell lines and animal models, but it is the first time that researchers have found that ginsenoside Rh2 could inhibit autophagy to work against cervical cancer.

Autophagy is a process where dysfunctional cellular components go degraded within cells mediated by lysosomes. As a form of programmed cell death, autophagy seems to play a part in killing tumor cells, but there have recently been strong arguments that autophagic activity might be pro-survival, which allows the tumor cells to overcome nutrient-limiting conditions and promote tumor growth.

The study confirmed that autophagy played a pro-survival role in cervical cancer cells, and ginsenoside Rh2 could act as an autophagy inhibitor to induce apoptosis in cervical cancer cell lines.

Another rare ginsenoside Rg5 also showed potential as a cytotoxic drug for the treatment of cervical cancer. It was found to induce apoptosis and DNA damage in human cervical cancer cells, in a study published in the journal Molecular Medicine Reports.

When cancer patients decide to try a ginseng supplement to support their cancer treatment, products containing a high concentration of rare ginsenosides are good options because they are highly bioactive and potent enough to exert substantial health-promoting effects.

It shall be noted that ginsenoside supplements might interact with some medications, so you shall always consult your doctor before using any herbal supplements.


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